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Potent analgesic effects of GDNF in neuropathic pain states | | T J Boucher
; K Okuse
; D L Bennett
; J B Munson
; J N Wood
; S B McMahon
; | | Date: |
6 Oct 2000 | | Journal: | Science, 290 (5489), 124-7 | | Abstract: | Neuropathic pain arises as a debilitating consequence of nerve injury. The etiology of such pain is poorly understood, and existing treatment is largely ineffective. We demonstrate here that glial cell line-derived neurotrophic factor (GDNF) both prevented and reversed sensory abnormalities that developed in neuropathic pain models, without affecting pain-related behavior in normal animals. GDNF reduces ectopic discharges within sensory neurons after nerve injury. This may arise as a consequence of the reversal by GDNF of the injury-induced plasticity of several sodium channel subunits. Together these findings provide a rational basis for the use of GDNF as a therapeutic treatment for neuropathic pain states. | | Source: | PubMed, pmid11021795 doi: 8887 | | Services: | Forum | Review | Favorites | |
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