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26 April 2024 |
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Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6 | | D Yang
; O Chertov
; S N Bykovskaia
; Q Chen
; M J Buffo
; J Shogan
; M Anderson
; J M Schröder
; J M Wang
; O M Howard
; J J Oppenheim
; | | Date: |
15 Oct 1999 | | Journal: | Science, 286 (5439), 525-8 | | Abstract: | Defensins contribute to host defense by disrupting the cytoplasmic membrane of microorganisms. This report shows that human beta-defensins are also chemotactic for immature dendritic cells and memory T cells. Human beta-defensin was selectively chemotactic for cells stably transfected to express human CCR6, a chemokine receptor preferentially expressed by immature dendritic cells and memory T cells. The beta-defensin-induced chemotaxis was sensitive to pertussis toxin and inhibited by antibodies to CCR6. The binding of iodinated LARC, the chemokine ligand for CCR6, to CCR6-transfected cells was competitively displaced by beta-defensin. Thus, beta-defensins may promote adaptive immune responses by recruiting dendritic and T cells to the site of microbial invasion through interaction with CCR6. | | Source: | PubMed, pmid10521347 doi: 7901 | | Services: | Forum | Review | Favorites | |
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