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26 April 2024 |
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Mechanism of suppression of cell-mediated immunity by measles virus | | C L Karp
; M Wysocka
; L M Wahl
; J M Ahearn
; P J Cuomo
; B Sherry
; G Trinchieri
; D E Griffin
; | | Date: |
12 Jul 1996 | | Journal: | Science, 273 (5272), 228-31 | | Abstract: | The mechanisms underlying the profound suppression of cell-mediated immunity (CMI) accompanying measles are unclear. Interleukin-12 (IL-12), derived principally from monocytes and macrophages, is critical for the generation of CMI. Measles virus (MV) infection of primary human monocytes specifically down-regulated IL-12 production. Cross-linking of CD46, a complement regulatory protein that is the cellular receptor for MV, with antibody or with the complement activation product C3b similarly inhibited monocyte IL-12 production, providing a plausible mechanism for MV-induced immunosuppression. CD46 provides a regulatory link between the complement system and cellular immune responses. | | Source: | PubMed, pmid8662504 | | Services: | Forum | Review | Favorites | |
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