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Blocked signal transduction to the ERK and JNK protein kinases in anergic CD4+ T cells | | W Li
; C D Whaley
; A Mondino
; D L Mueller
; | | Date: |
1 Mar 1996 | | Journal: | Science, 271 (5253), 1272-6 | | Abstract: | T cells activated by antigen receptor stimulation in the absence of accessory cell-derived costimulatory signals lose the capacity to synthesize the growth factor interleukin-2 (IL-2), a state called clonal anergy. An analysis of CD3- and CD28-induced signal transduction revealed reduced ERK and JNK enzyme activities in murine anergic T cells. The amounts of ERK and JNK proteins were unchanged, and the kinases could be fully activated in the presence of phorbol 12-myristate 13-acetate. Dephosphorylation of the calcineurin substrate NFATp (preexisting nuclear factor of activated T cells) also remained inducible. These results suggest that a specific block in the activation of ERK and JNK contributes to defective IL-2 production in clonal anergy. | | Source: | PubMed, pmid8638107 | | Services: | Forum | Review | Favorites | |
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