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The adjuvant effect of interleukin-12 in a vaccine against Leishmania major | | L C Afonso
; T M Scharton
; L Q Vieira
; M Wysocka
; G Trinchieri
; P Scott
; | | Date: |
14 Jan 1994 | | Journal: | Science, 263 (5144), 235-7 | | Abstract: | Protection induced by vaccination depends on the capacity of the vaccine to elicit an appropriate immune response. In leishmaniasis, protection requires leishmanial-specific CD4+ T helper (TH) cells. Vaccination of BALB/c mice with leishmanial antigens and interleukin-12 (IL-12) promoted the development of leishmanial-specific CD4+ TH1 cells. These mice were resistant to subsequent infection with Leishmania major. Thus, IL-12 is an effective adjuvant for the initiation of protective cell-mediated immunity against leishmaniasis and may be an important component in other vaccines that need to induce cell-mediated immunity. | | Source: | PubMed, pmid7904381 | | Services: | Forum | Review | Favorites | |
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