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26 April 2024 |
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Human immunodeficiency virus infection of human-PBL-SCID mice | D E Mosier
; R J Gulizia
; S M Baird
; D B Wilson
; D H Spector
; S A Spector
; | Date: |
15 Feb 1991 | Journal: | Science, 251 (4995), 791-4 | Abstract: | Severe combined immunodeficient (SCID) mice reconstituted with human peripheral blood leukocytes (hu-PBL-SCID mice) have inducible human immune function and may be useful as a small animal model for acquired immunodeficiency syndrome (AIDS) research. Hu-PBL-SCID mice infected with human immunodeficiency virus-1 (HIV-1) contained virus that was recoverable by culture from the peritoneal cavity, spleen, peripheral blood, and lymph nodes for up to 16 weeks after infection; viral sequences were also detected by in situ hybridization and by amplification with the polymerase chain reaction (PCR). Mice could be infected with multiple strains of HIV-1, including LAV-1/Bru, IIIB, MN, SF2, and SF13. HIV-1 infection affected the concentration of human immunoglobulin and the number of CD4+ T cells in the mice. These results support the use of the hu-PBL-SCID mouse for studies of the pathogenesis and treatment of AIDS. | Source: | PubMed, pmid1990441 | Services: | Forum | Review | Favorites |
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