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Expression of the pX gene of HTLV-I: general splicing mechanism in the HTLV family | | M Seiki
; A Hikikoshi
; T Taniguchi
; M Yoshida
; | | Date: |
28 Jun 1985 | | Journal: | Science, 228 (4707), 1532-4 | | Abstract: | Human T-cell leukemia virus type I (HTLV-I) is an etiological agent of adult T-cell leukemia. A viral gene pX encodes for p40X and it has been proposed that this protein trans-activates the viral long terminal repeat and possibly some cellular genes; this activation may be associated with T-cell transformation. The mechanism of pX gene expression and the primary structure of p40X are now reported. Two-step splicing generates the 2.1-kilobase pX mRNA; the initiator methionine for env becomes part of the pX protein. These splicing signals are conserved among all members of the HTLV family except for the acquired immune deficiency syndrome-associated viruses. | | Source: | PubMed, pmid2990031 | | Services: | Forum | Review | Favorites | |
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