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26 April 2024 |
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Antileukemic principles isolated from euphorbiaceae plants | | S M Kupchan
; I Uchida
; A R Branfman
; R G Dailey
; B Y Fei
; | | Date: |
13 Feb 1976 | | Journal: | Science, 191 (4227), 571-2 | | Abstract: | Extracts of Euphorbia esula L. and Croton tiglium L., two members of the Euphorbiaceae which have been used widely in folk medicine for treating cancers, showed antileukemic activity against the P-388 lymphocytic leukemia in mice. Systematic fractionation of the extract of Euphorbia esula L. led to characterization of a major antileukemic component as the new diterpenoid diester, ingenol 3,20-dibenzoate. Similar fractionation of Croton oil led to characterization of phorbol 12-tiglate 13-decanoate as an active principle. | | Source: | PubMed, pmid1251193 | | Services: | Forum | Review | Favorites | |
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