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26 April 2024 |
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Article overview
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Silent hemoglobin alpha genes in apes: potential source of thalassemia | | S H Boyer
; A N Noyes
; G R Vrablik
; L J Donaldson
; E W Schaefer
; C W Gray
; T F Thurmon
; | | Date: |
15 Jan 1971 | | Journal: | Science, 171 (967), 182-5 | | Abstract: | Small quantities of unusual hemoglobins were found in 1 of 37 chimpanzees and 2 of 6 gorillas. In each genus these hemoglobins contain unique alpha chains that differ from the ordinary by eight to nine scattered amino acid changes. The unusual chains arise from a hitherto undetected hemoglobin (3)alpha locus. No (3)alpha products are found in most apes; accordingly, (3)alpha is considered synthetically inactive in all but a few reversion mutants. Indirect evidence that the inactive (3)alpha locus is juxtaposed to an active alpha locus together with the supposition that (3)alpha exists in man provides a setting wherein thalassemia might be produced by nonhomologous recombination between two loci. | | Source: | PubMed, pmid5540329 | | Services: | Forum | Review | Favorites | |
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