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Similarity-Detection and Localization | | Terence Hwa
; Michael Lassig
; | | Date: |
15 Nov 1995 | | Subject: | Condensed Matter; Cellular Automata and Lattice Gases; Quantitative Methods | cond-mat comp-gas nlin.CG q-bio.QM | | Affiliation: | UC San Diego) and Michael Lassig (Max-Planck Inst | | Abstract: | The detection of similarities between long DNA and protein sequences is studied using concepts of statistical physics. It is shown that mutual similarities can be detected by sequence alignment methods only if their amount exceeds a threshold value. The onset of detection is a continuous phase transition which can be viewed as a localization-delocalization transition. The ``fidelity’’ of the alignment is the order parameter of that transition; it leads to criteria for the selection of optimal alignment parameters. | | Source: | arXiv, cond-mat/9511072 | | Services: | Forum | Review | PDF | Favorites | |
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