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26 April 2024

» arxiv » 1308.6737

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Enhanced Tumor Accumulation of Sub-2 nm Gold Nanoclusters for Cancer Radiation Therapy
Xiao-Dong Zhang ; Jie Chen ; Zhentao Luo ; Di Wu ; Xiu Shen ; Sha-Sha Song ; Yuan-Ming Sun ; Pei-Xun Liu ; Jing Zhao ; Shuaidong Huo ; Saijun Fan ; Feiyue Fan ; Xing-Jie Liang ; Jianping Xie ;
Date:	30 Aug 2013
Abstract:	A new type of metabolizable and efficient radiosensitizer for cancer radiotherapy is presented in this study by combining ultrasmall Au nanoclusters (NCs, <2 nm) with biocompatible coating ligands (glutathione, GSH). The new nano-construct (GSH-coated Au25 NCs) inherits attractive features of both the Au core (strong radiosensitizing effect) and GSH shell (good biocompatibility). It can preferentially accumulate in tumor via the improved EPR effect, which leads to strong enhancement for cancer radiotherapy. After the treatment, the small-sized GSH-Au25 NCs can be efficiently cleared by the kidney, minimizing any potential side effects due to the accumulation of Au25 NCs in the body.
Source:	arXiv, 1308.6737
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