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Helicase activity on DNA as a propagating front | | Somendra M. Bhattacharjee
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16 Jul 2003 | | Journal: | Europhysics Letts. 65, 574 (2004) | | Subject: | Soft Condensed Matter; Statistical Mechanics; Biological Physics | cond-mat.soft cond-mat.stat-mech physics.bio-ph q-bio | | Abstract: | We develop a propagating front analysis, in terms of a local probability of zipping, for the helicase activity of opening up a double stranded DNA (dsDNA). In a fixed-distance ensemble (conjugate to the fixed-force ensemble) the front separates the zipped and unzipped phases of a dsDNA and a drive acts locally around the front. Bounds from variational analysis and numerical estimates for the speed of a helicase are obtained. Different types of helicase behaviours can be distinguished by the nature of the drive. | | Source: | arXiv, cond-mat/0307380 | | Services: | Forum | Review | PDF | Favorites | |
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