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Dynamic instability of microtubules: effect of catastrophe-suppressing drugs | | Pankaj Kumar Mishra
; Ambarish Kunwar
; Sutapa Mukherji
; Debashish Chowdhury
; | | Date: |
23 Oct 2003 | | Subject: | Statistical Mechanics; Soft Condensed Matter; Subcellular Processes | cond-mat.stat-mech cond-mat.soft q-bio.SC | | Abstract: | Microtubules are stiff filamentary proteins that constitute an important component of the cytoskeleton of cells. These are known to exhibit a dynamic instability. A steadily growing microtubule can suddenly start depolymerizing very rapidly; this phenomenon is known as ``catastrophe’’. However, often a shrinking microtubule is ``rescued’’ and starts polymerizing again. Here we develope a model for the polymerization-depolymerization dynamics of microtubules in the presence of {it catastrophe-suppressing drugs}. Solving the dynamical equations in the steady-state, we derive exact analytical expressions for the length distributions of the microtubules tipped with drug-bound tubulin subunits as well as those of the microtubules, in the growing and shrinking phases, tipped with drug-free pure tubulin subunits. We also examine the stability of the steady-state solutions. | | Source: | arXiv, cond-mat/0310546 | | Other source: | [GID 356065] pmid16383652 | | Services: | Forum | Review | PDF | Favorites | |
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