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Enhancement of the stability of genetic switches by overlapping upstream regulatory domains | | Patrick B. Warren
; Pieter Rein ten Wolde
; | | Date: |
1 Nov 2003 | | Subject: | Molecular Networks | q-bio.MN | | Abstract: | We study genetic switches formed from pairs of mutually repressing operons. The switch stability is characterised by a well defined lifetime which grows sub-exponentially with the number of copies of the most-expressed transcription factor, in the regime accessible by our numerical simulations. The stability can be markedly enhanced by a suitable choice of overlap between the upstream regulatory domains. Our results suggest that robustness against biochemical noise can provide a selection pressure that drives operons, that regulate each other, together in the course of evolution. | | Source: | arXiv, q-bio.MN/0310041 | | Other source: | [GID 734365] pmid15089712 | | Services: | Forum | Review | PDF | Favorites | |
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