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The role of M cells and the long QT syndrome in cardiac arrhythmias: simulation studies of reentrant excitations using a detailed electrophysiological model | | Hervé Henry
; Wouter-Jan Rappel
; | | Date: |
19 Jul 2004 | | Journal: | Chaos Vol 14 pages 172-182 (2004) DOI: 10.1063/1.1636272 | | Subject: | Tissues and Organs; Pattern Formation and Solitons; Other | q-bio.TO cond-mat.other nlin.PS q-bio.OT | | Abstract: | In this numerical study, we investigate the role of intrinsic heterogeneities of cardiac tissue due to M cells in the generation and maintenance of reentrant excitations using the detailed Luo-Rudy dynamic model. This model has been extended to include a description of the long QT 3 syndrome, and is studied in both one dimension, corresponding to a cable traversing the ventricular wall, and two dimensions, representing a transmural slice. We focus on two possible mechanisms for the generation of reentrant events. We first investigate if early-after-depolarizations occurring in M cells can initiate reentry. We find that, even for large values of the long QT strength, the electrotonic coupling between neighboring cells prevents early-after-depolarizations from creating a reentry. We then study whether M cell domains, with their slow repolarization, can function as wave blocks for premature stimuli. We find that the inclusion of an M cell domain can result in some cases in reentrant excitations and we determine the lifetime of the reentry as a function of the size and geometry of the domain and of the strength of the long QT syndrome. | | Source: | arXiv, q-bio.TO/0407027 | | Services: | Forum | Review | PDF | Favorites | |
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