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Universal 1/f noise, cross-overs of scaling exponents, and chromosome specific patterns of GC content in DNA sequences of the human genome | | Wentian Li
; Dirk Holste
; | | Date: |
3 Nov 2004 | | Subject: | Genomics; Biomolecules | q-bio.GN q-bio.BM | | Abstract: | Spatial fluctuations of guanine and cytosine base content (GC%) are studied by spectral analysis for the complete set of human genomic DNA sequences. We find that (i) the 1/f^alpha decay is universally observed in the power spectra of all twenty-four chromosomes, and that (ii) the exponent alpha approx 1 extends to about 10^7 bases, one order of magnitude longer than what has previously been observed. We further find that (iii) almost all human chromosomes exhibit a cross-over from alpha_1 approx 1 (1/f^alpha_1) at lower frequency to alpha_2 < 1 (1/f^alpha_2) at higher frequency, typically occurring at around 30,000--100,000 bases, while (iv) the cross-over in this frequency range is virtually absent in human chromosome 22. In addition to the universal 1/f^alpha noise in power spectra, we find (v) several lines of evidence for chromosome-specific correlation structures, including a 500,000 bases long oscillation in human chromosome 21. The universal 1/f^alpha spectrum in human genome is further substantiated by a resistance to variance reduction in guanine and cytosine content when the window size is increased. | | Source: | arXiv, q-bio.GN/0411016 | | Services: | Forum | Review | PDF | Favorites | |
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