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Yeast Protein Interactome Topology Provides Framework for Coordinated-Functionality | | Andre X. C. N. Valente
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3 May 2005 | | Subject: | Molecular Networks; Other; Statistical Mechanics; Other | q-bio.MN cond-mat.other cond-mat.stat-mech q-bio.OT | | Abstract: | The network of all pairwise protein physical interactions - the interactome - constitutes a key foundation for an integrated, post-genomic, study of an organism. Experimentally, the challenge lies in refining high-throughput capable techniques to generate more accurate and complete interactome data sets. In parallel, a theoretical challenge is turning these large interaction data sets (e.g., rough estimates predict 40 000-200 000 interactions in human) into meaningful maps - true guides to understanding and further exploring the biology of an organism. Taking the yeast Saccharomyces cerevisiae interactome as a case study, we show here that, by combining two complementary theoretical network measures, betweenness centrality and `Q-modularity’, a clearer picture of an interactome architecture is obtained. In particular, we suggest that the topology of the yeast interactome provides an ideal framework for the cell to physically implement the biological concept of coordinated yet distinct functional modules. Interestingly, this functional coordination would not hinge specially on hubs, proteins with a large number of interactions. This unique non-hub-centric hierarchical organization is not reproduced by gene duplication-and-divergence stochastic growth models that disregard selective pressures. | | Source: | arXiv, q-bio.MN/0505006 | | Services: | Forum | Review | PDF | Favorites | |
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