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A Thermodynamic Model for Receptor Clustering | | Chinlin Guo
; Herbert Levine
; | | Date: |
6 Aug 1999 | | Subject: | Soft Condensed Matter; Subcellular Processes | cond-mat.soft q-bio.SC | | Abstract: | Intracellular signaling often arises from ligand-induced oligomerization of cell surface receptors. This oligomerization or clustering process is fundamentally a cooperative behavior between near-neighbor receptor molecules; the properties of this cooperative process clearly affects the signal transduction. Recent investigations have revealed the molecular basis of receptor-receptor interactions, but a simple theoretical framework for using this data to predict cluster formation has been lacking. Here, we propose a simple, coarse-grained, phenomenological model for ligand-modulated receptor interactions and discuss its equilibrium properties via mean-field theory. The existence of a first-order transition for this model has immediate implications regarding the robustness of the cellular signaling response. | | Source: | arXiv, cond-mat/9908106 | | Services: | Forum | Review | PDF | Favorites | |
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