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The thermodynamics of general anesthesia | | Thomas Heimburg
; Andrew D. Jackson
; | | Date: |
19 Oct 2006 | | Subject: | Biological Physics; Medical Physics | | Abstract: | It is known that the action of general anesthetics is proportional to their partition coefficient in lipid membranes (Meyer-Overton rule). This solubility is, however, directly related to the depression of the temperature of the melting transition found close to body temperature in biomembranes. We propose a thermodynamic extension of the Meyer-Overton rule which is based on free energy changes in the system and thus automatically incorporates the effects of melting point depression. This model provides a quantitative explanation of the pressure reversal of anesthesia. Further, it explains why inflammation and the addition of divalent cations reduce the effectiveness of anesthesia. | | Source: | arXiv, physics/0610147 | | Services: | Forum | Review | PDF | Favorites | |
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