Science-advisor
REGISTER info/FAQ
Login
username
password
     
forgot password?
register here
 
Research articles
  search articles
  reviews guidelines
  reviews
  articles index
My Pages
my alerts
  my messages
  my reviews
  my favorites
 
 
Stat
Members: 3647
Articles: 2'510'585
Articles rated: 2609

05 May 2024
 
  » 1056466

 Article forum



Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
D Schenk ; R Barbour ; W Dunn ; G Gordon ; H Grajeda ; T Guido ; K Hu ; J Huang ; K Johnson-Wood ; K Khan ; D Kholodenko ; M Lee ; Z Liao ; I Lieberburg ; R Motter ; L Mutter ; F Soriano ; G Shopp ; N Vasquez ; C Vandevert ; S Walker ; M Wogulis ; T Yednock ; D Games ; P Seubert ;
Date 8 Jul 1999
Journal Nature, 400 (6740), 173-7
AbstractAmyloid-beta peptide (Abeta) seems to have a central role in the neuropathology of Alzheimer’s disease (AD). Familial forms of the disease have been linked to mutations in the amyloid precursor protein (APP) and the presenilin genes. Disease-linked mutations in these genes result in increased production of the 42-amino-acid form of the peptide (Abeta42), which is the predominant form found in the amyloid plaques of Alzheimer’s disease. The PDAPP transgenic mouse, which overexpresses mutant human APP (in which the amino acid at position 717 is phenylalanine instead of the normal valine), progressively develops many of the neuropathological hallmarks of Alzheimer’s disease in an age- and brain-region-dependent manner. In the present study, transgenic animals were immunized with Abeta42, either before the onset of AD-type neuropathologies (at 6 weeks of age) or at an older age (11 months), when amyloid-beta deposition and several of the subsequent neuropathological changes were well established. We report that immunization of the young animals essentially prevented the development of beta-amyloid-plaque formation, neuritic dystrophy and astrogliosis. Treatment of the older animals also markedly reduced the extent and progression of these AD-like neuropathologies. Our results raise the possibility that immunization with amyloid-beta may be effective in preventing and treating Alzheimer’s disease.
Source PubMed, pmid10408445 doi: 10.1038/22124
Services Forum | Review | Favorites   
 

No message found in this article forum.  You have a question or message about this article? Ask the community and write a message in the forum.
If you want to rate this article, please use the review section..

Subject of your forum message:
Write your forum message below (min 50, max 2000 characters)

2000 characters left.
Please, read carefully your message since you cannot modify it after submitting.

  To add a message in the forum, you need to login or register first. (free): registration page






ScienXe.org
» my Online CV
» Free

home  |  contact  |  terms of use  |  sitemap
Copyright © 2005-2024 - Scimetrica