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Brownian dynamics simulation of directional sliding of histone octamers caused by DNA bending | | Wei Li
; Shuo-Xing Dou
; Ping Xie
; Peng-Ye Wang
; | | Date: |
30 Apr 2006 | | Journal: | Phys Rev E, 73 (5 Pt 1), 051909 | | Abstract: | Chromatin-remodeling complexes such as SWI/SNF and RSC of yeast can perturb the structure of nucleosomes in an ATP-dependent manner. Experimental results prove that this chromatin remodeling process involves DNA bending. We simulate the effect of DNA bending, caused by chromatin-remodeling complexes, on directional sliding of histone octamers by Brownian dynamics simulation. The simulation results show that, after a DNA loop being generated at the side of a nucleosome, the histone octamer slides towards this DNA loop until the loop disappears. The DNA loop size is an important factor affecting the process of directional sliding of the histone octamer. | | Source: | PubMed, pmid16802969 | | Services: | Forum | Review | Favorites | |
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