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Timing the ancestor of the HIV-1 pandemic strains | | B Korber
; M Muldoon
; J Theiler
; F Gao
; R Gupta
; A Lapedes
; B H Hahn
; S Wolinsky
; T Bhattacharya
; | | Date: |
9 Jun 2000 | | Journal: | Science, 288 (5472), 1789-96 | | Abstract: | HIV-1 sequences were analyzed to estimate the timing of the ancestral sequence of the main group of HIV-1, the strains responsible for the AIDS pandemic. Using parallel supercomputers and assuming a constant rate of evolution, we applied maximum-likelihood phylogenetic methods to unprecedented amounts of data for this calculation. We validated our approach by correctly estimating the timing of two historically documented points. Using a comprehensive full-length envelope sequence alignment, we estimated the date of the last common ancestor of the main group of HIV-1 to be 1931 (1915-41). Analysis of a gag gene alignment, subregions of envelope including additional sequences, and a method that relaxed the assumption of a strict molecular clock also supported these results. | | Source: | PubMed, pmid10846155 doi: 8571 | | Services: | Forum | Review | Favorites | |
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