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05 February 2025

» pubmed » pmid10846166

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mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination
T Ichise ; M Kano ; K Hashimoto ; D Yanagihara ; K Nakao ; R Shigemoto ; M Katsuki ; A Aiba ;
Date:	9 Jun 2000
Journal:	Science, 288 (5472), 1832-5
Abstract:	Targeted deletion of metabotropic glutamate receptor-subtype 1 (mGluR1) gene can cause defects in development and function in the cerebellum. We introduced the mGluR1alpha transgene into mGluR1-null mutant [mGluR1 (-/-)] mice with a Purkinje cell (PC)-specific promoter. mGluR1-rescue mice showed normal cerebellar long-term depression and regression of multiple climbing fiber innervation, events significantly impaired in mGluR1 (-/-) mice. The impaired motor coordination was rescued by this transgene, in a dose-dependent manner. We propose that mGluR1 in PCs is a key molecule for normal synapse formation, synaptic plasticity, and motor control in the cerebellum.
Source:	PubMed, pmid10846166 doi: 8574
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