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PAX8-PPARgamma1 fusion oncogene in human thyroid carcinoma [corrected] | | T G Kroll
; P Sarraf
; L Pecciarini
; C J Chen
; E Mueller
; B M Spiegelman
; J A Fletcher
; | | Date: |
25 Aug 2000 | | Journal: | Science, 289 (5483), 1357-60 | | Abstract: | Chromosomal translocations that encode fusion oncoproteins have been observed consistently in leukemias/lymphomas and sarcomas but not in carcinomas, the most common human cancers. Here, we report that t(2;3)(q13;p25), a translocation identified in a subset of human thyroid follicular carcinomas, results in fusion of the DNA binding domains of the thyroid transcription factor PAX8 to domains A to F of the peroxisome proliferator-activated receptor (PPAR) gamma1. PAX8-PPARgamma1 mRNA and protein were detected in 5 of 8 thyroid follicular carcinomas but not in 20 follicular adenomas, 10 papillary carcinomas, or 10 multinodular hyperplasias. PAX8-PPARgamma1 inhibited thiazolidinedione-induced transactivation by PPARgamma1 in a dominant negative manner. The experiments demonstrate an oncogenic role for PPARgamma and suggest that PAX8-PPARgamma1 may be useful in the diagnosis and treatment of thyroid carcinoma. | | Source: | PubMed, pmid10958784 doi: 8756 | | Services: | Forum | Review | Favorites | |
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