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Inhibition of experimental allergic encephalomyelitis in rats severely depleted of T cells | | N K Gonatas
; J C Howard
; | | Date: |
29 Nov 1974 | | Journal: | Science, 186 (4166), 839-41 | | Abstract: | Lewis rats depleted of thymus-derived cells (B rats) failed to develop either experimental allergic encephalomyelitis or antibody against myelin basic protein. Lewis B rats reconstituted with 690 x 10(6) thymocytes developed experimental allergic encephalomyelitis and levels of antibody against myelin basic protein comparable to those of controls. The Lewis B rat model should be useful in the analysis of the role of thymus-derived cell populations and antibody in the induction of experimental allergic encephalomyelitis. | | Source: | PubMed, pmid4143378 | | Services: | Forum | Review | Favorites | |
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