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Dexamethasone stimulation of murine mammary tumor virus expression: a tissue culture source of virus | | W P Parks
; E M Scolnick
; E H Kozikowski
; | | Date: |
12 Apr 1974 | | Journal: | Science, 184 (133), 158-60 | | Abstract: | In mouse cell lines derived from mammary adenocarcinomnas, the synthetic steroid dexamnethasone stimulates production of murine mammary tumor virus. Viral RNA and antigens are increased as much as 20-fold, and culture fluid supernatants from steroid-treated cells contain type B particles with reverse transcriptase. These cells provide a possible tissue culture source of this virus and a model system for studying the mechanism of action of corticosteroids and the regulation of transcription of integrated viral DNA. | | Source: | PubMed, pmid4361099 | | Services: | Forum | Review | Favorites | |
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