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26 April 2024 |
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Acetylenic analog of arachidonate that acts like aspirin on platelets | | A L Willis
; D C Kuhn
; H J Weiss
; | | Date: |
25 Jan 1974 | | Journal: | Science, 183 (122), 327-30 | | Abstract: | Development of irreversible platelet aggregation and the accompanying release of platelet-bound serotonin and production of prostaglandins is suppressed by 5,8,11,14-eicosatetraynoic acid (TYA). These findings may be explained by an ability of TYA to inhibit the enzymatic conversion of arachidonate to a newly recognized factor, labile aggregation-stimulating substance, which induces platelet aggregation, and to prostaglandins E(2) and F(2alpha). | | Source: | PubMed, pmid4809077 | | Services: | Forum | Review | Favorites | |
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