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Compensatory increase in tyrosine hydroxylase activity in rat brain after intraventricular injections of 6-hydroxydopamine | | A L Acheson
; M J Zigmond
; E M Stricker
; | | Date: |
1 Feb 1980 | | Journal: | Science, 207 (4430), 537-40 | | Abstract: | The neurotoxin 6-hydroxydopamine produced a permanent loss of endogenous norepinephrine and of 3H-labeled norepinephrine uptake sites in the hippocampus within 5 days. These losses were initially accompanied by parallel decreases in tyrosine hydroxylase activity and synaptosomal norepinephrine synthesis. Within 21 days, however, hippocampal tyrosine hydroxylase activity and norepinephrine synthesis rate increased three- to fivefold. These data suggest a novel form of plasticity in brain-damaged animals characterized by an increase in the capacity for transmitter biosynthesis in residual neurons. | | Source: | PubMed, pmid6101509 | | Services: | Forum | Review | Favorites | |
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