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Cellular site of opiate dependence | | H O Collier
; | | Date: |
14 Feb 1980 | | Journal: | Nature, 283 (5748), 625-9 | | Abstract: | Experiments on whole animals, guinea pig isolated ileum, individual neurones in situ and cultured neuroblastoma--glioma hybrid cells indicate that opiate dependence and associated tolerance develop within neurones bearing specific opiate receptors (opiate-sensitive neurones). The essential change appears to be an hypertrophy of the cyclic AMP system, in response to inhibition by opiate of a neuronal adenylate cyclase. | | Source: | PubMed, pmid6243745 | | Services: | Forum | Review | Favorites | |
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