| | |
| | |
Stat |
Members: 3647 Articles: 2'511'329 Articles rated: 2609
06 May 2024 |
|
| | | |
|
Article overview
| |
|
Inducible repair of thymine glycol detected by an ultrasensitive assay for DNA damage | X C Le
; J Z Xing
; J Lee
; S A Leadon
; M Weinfeld
; | Date: |
15 May 1998 | Journal: | Science, 280 (5366), 1066-9 | Abstract: | An ultrasensitive assay for measuring DNA base damage is described that couples immunochemical recognition with capillary electrophoresis and laser-induced fluorescence detection. The method provides a detection limit of 3 x 10(-21) moles, an improvement of four to five orders of magnitude over current methods. Induction and repair of thymine glycols were studied in irradiated A549 cells (a human lung carcinoma cell line). Exposure of these cells to a low dose of radiation (0.25 Gray) 4 hours before a clinically relevant dose (2 Gray) enhanced removal of thymine glycols after the higher dose. These data provide evidence for an inducible repair response for radiation-induced damage to DNA bases. | Source: | PubMed, pmid9582118 | Services: | Forum | Review | Favorites |
|
|
No review found.
Did you like this article?
Note: answers to reviews or questions about the article must be posted in the forum section.
Authors are not allowed to review their own article. They can use the forum section.
|
| |
|
|
|